Secondary Metabolites from the Fungus Chaetomium brasiliense |
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| Authors: | Guo‐You Li Bo‐Gang Li Tao Yang Guang‐Ye Liu Guo‐Lin Zhang |
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| Affiliation: | Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P.?R. China, (phone/fax: +86‐28‐85225401) |
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| Abstract: | Two new depsidones, mollicellins I and J ( 1 and 2 , resp.), and a new chromone, 2‐(hydroxymethyl)‐6‐methylmethyleugenin ( 3 ), along with six known compounds, 4 – 9 , were isolated from the ethyl acetate extract of a solid‐state fermented culture of Chaetomium brasiliense. Their structures were elucidated based on spectroscopic analysis. Mollicellins I and H ( 5 ) exhibited significant growth inhibitory activity against human breast cancer (Bre04), human lung (Lu04), and human neuroma (N04) cell lines with GI50 values between 2.5–8.6 μg/ml. |
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| Keywords: | Chaetomium brasiliense Depsidones Mollicellins I and J Chromones Cytotoxic activity Metabolites Fungus |
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