Facile Solid‐Phase Organic Synthesis of 5‐Vinyl‐Substituted 1,2,4‐Oxadiazoles from Polymer‐Bound α‐Selenopropionic Acid |
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| Authors: | Qiao‐Sheng Hu Shou‐Ri Sheng Xiao‐Ling Liu Fang Hu Ming‐Zhong Cai |
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| Institution: | 1. College of Chemistry and Life Science, Gannan Normal University, Ganzhou 341000, P. R. China;2. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330027, P. R. China |
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| Abstract: | Cyclocondensation of polystyrene‐supported α‐selenopropionic acid with amidoximes in the presence of 1‐(3‐dimethylaminopropyl)‐3‐ethylcarbodiimide hydrochloride (EDC) followed by oxidative deselenation efficiently afforded 5‐vinyl 1,2,4‐oxadiazoles in good yield and purity with a facile work‐up procedure. |
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| Keywords: | Solid‐phase organic synthesis Polystyrene‐supported α ‐selenopropionic acid 5‐Vinyl‐substituted 1 2 4‐oxadiazole |
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