1. Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Department of Chemistry, Zhengzhou 450052;2. Key laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084
Abstract:
A series of nitrogen mustard derivatives were synthesized by chloroform reaction and coupling reaction using DCC/ HOBT as promoting additives. The structure of compound was confirmed by 1H NMR, 31P NMR, MS and IR. The data show that the nitrogen mustard with tripolypyrrole as the linker inhibits all the four tested cells and has the highest activity.
