1. Department of Food Science and Technology, National Fisheries University, Nagatahonmachi, Shimonoseki 759‐6595, Japan;2. Department of Applied Chemistry, Faculty of Engineering, Kyushu Institute of Technology, Tobata‐ku, Kitakyushu 804‐8550, Japan;3. Department of Food Science and Technology, Tokyo University of Agriculture, Abashiri, Hokkaido 099‐2493
Abstract:
Asterriquinone D was easily synthesized in three steps from 2,5‐dichloro‐1,4‐benzoquinone. The reaction of benzoquinone with indole in the presence of Pd(OAc)2, followed by oxidation with cerium (IV) ammonium nitrate (CAN) produced 3,6‐dichloro‐2,5‐bis (3‐indolyl)‐1,4‐benzoquinone. The methoxylation of the dichloride with NaOH in CH3OH afforded asterriquinone D.
