Synthesis and Characterization of New Binaphthyl‐Linked Phenanthroline‐, Bipyridine‐, or Pyridine‐Derived Ligands,and the Study of Their Cytotoxic Activity |
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| Authors: | Nesrin Beynek Gühergül Uluçam Kadriye Benkli Ays̨e Tansu Koparal |
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| Institution: | 1. Department of Chemistry, Faculty of Art and Science, University of Trakya, TR‐22030 Edirne, (phone: +90?284?2359592/1228;2. fax: +90?284?2351198);3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu, TR‐26470 Eskisehir;4. Department of Biology, Faculty of Science, University of Anadolu, TR‐26470 Eskisehir |
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| Abstract: | In the present work, we describe the synthesis and characterization of five new versatile acyclic or macrocyclic ligands containing binaphthyl‐linked pyridine, bipyridine, or phenanthroline groups in their framework (see Schemes 1–4). The structures of the ligands were elucidated on the basis of elemental analyses, IR, 1H‐NMR, 13C‐NMR, and FAB mass spectra. The cytotoxicity of these compounds was tested in vitro by using the tetrazolium salt reduction (MTT) assay on A549 (human lung carcinoma epithelial like) cells. All of the tested compounds induced time‐ and concentration‐dependent cytotoxic effect. |
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| Keywords: | Macrocyclic ligands 1 1′ ‐Binaphthyl Pyridines 2 2′ ‐Bipyridine Phenanthroline Cytotoxic activity |
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