Substituted Pyrazolo[3,4‐d]pyrimidines: Microwave‐Assisted,Solvent‐Free Synthesis and Biological Evaluation |
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| Authors: | Ana?M?F Oliveira‐Campos Aravind Sivasubramanian Lígia?M Rodrigues Julio?A Seijas M Pilar?Vázquez‐Tato Francisco Peixoto Carlos?G Abreu Honorina Cidade Ana?Elizabete Oliveira Madalena Pinto |
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| Institution: | 1. Centro de Química, Universidade do Minho, PT‐4710‐057 Braga, (fax: +351253604382);2. Departamento de Química Organica, Facultad de Ciencias, Universidad de Santiago de Compostela, ES‐27080 Lugo;3. CECAV, UTAD, PT‐5001‐801 Vila Real;4. Dept. Plant Protect. UTAD, PT‐5001‐801 Vila Real;5. CEQOFFUP, Laboratório de Química Organica, Faculdade de Farmácia, Universidade do Porto, PT‐4050‐047 Porto |
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| Abstract: | A simple and efficient method has been developed for the synthesis of various pyrazolo3,4‐d]pyrimidines by using microwave irradiation under solvent‐free conditions. The advantages of applying microwave irradiation compared with the classical method were demonstrated. The structures of all the compounds were confirmed by the usual techniques and, in two cases, by X‐ray analysis. The compounds did not display appreciable ability to inhibit xanthine oxidase activity. Screening for antifungal activity showed that some derivatives were active against four fungi, with more significant results for Botrytis. |
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| Keywords: | Pyrazolo[3 4‐d]pyrimidines Microwave‐assisted synthesis Antifungal activity Botrytis |
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