Division of Organic and Bioorganic Chemistry, Keio University Faculty of Pharmacy Shibakoen 1‐5‐30, Minato‐ku, Tokyo 105‐8512, Japan
Abstract:
We synthesized a series of bis(bromomethyl)‐1,10‐phenanthrolines as novel anticancer lead compounds and examined their DNA‐binding properties. 5,6‐Bis(bromomethyl)‐1,10‐phenanthroline showed DNA intercalating activity and DNA crosslinking activity, furthermore it is stable in aqueous solution.
