Design,Synthesis and Antitumor Activity of Asymmetric Bis(s‐triazole Schiff‐base)s Bearing Functionalized Side‐Chain |
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| Authors: | Guo‐Qiang HU Li‐Li HOU Song‐Qiang XIE Wen‐Long HUANG |
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| Institution: | 1. Institute of Pharmacy, Henan University, Kaifeng, Henan 475001, China;2. Center of Drug Discovery, China Pharmaceutical University, Nanjing, Jiangsu 210009, China |
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| Abstract: | 1‐Amino‐2‐pyrid‐3‐yl‐5‐(2‐benzoylethylthio)‐s‐triazole ( 1 ) was condensed with 1‐amino‐3‐mercapto‐5‐ (un)substituted phenyl]‐s‐triazoles and subsequently substituted with chloroacetic acid to afford bis‐s‐triazole sulfanylacetic acid mono‐Schiff bases ( 3a – 3e ), which were condensed with 9‐formylanthracene to produce asymmetric bis(s‐triazole Schiff base) sulfanylacetic acids ( 4a – 4e ). The structures of new synthesized compounds were characterized by elemental analysis and spectral data, and their in vitro antitumor activity against L1210, CHO and HL60 cell lines was evaluted via the respective IC50 values by methylthiazole trazolium (MTT) assay. |
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| Keywords: | s‐triazole bis(Schiff base) synthesis antitumor activity |
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