1. Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad‐431004 (MS), India;2. New Drug Discovery, Wockhardt Research Centre, Aurangabad‐431210 (MS), India
Abstract:
3,4‐Dihydropyrimidin‐2‐(1H)‐ones and their thione analogues are synthesized from the condensation of aromatic aldehydes, β‐dicarbonyl compound and urea or thiourea in presence of 5 mol% of oxalic acid in ethanol‐water (1:2; v/v) under mild reaction conditions. The yields obtained are better and also the use of very inexpensive catalyst, environmentally benign solvent and easy work‐up are the advantageous aspects of the present method.
