Bioactive Components from the Mycelium of Antrodia Salmonea |
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| Authors: | Chien‐Chang Shen Chwan‐Fwu Lin Yu‐Ling Huang Shr‐Ting Wan Chin‐Chu Chen Sen‐Je Sheu Yi‐Chin Lin Chien‐Chih Chen |
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| Institution: | 1. National Research Institute of Chinese Medicine, No. 155‐1, Sec. 2, Li Nung Street, Peitou, Taipei, Taiwan, R.O.C.;2. Department of Cosmetic Science, Chang Gung Institute of Technology, Tao‐Yuan, Taiwan, R.O.C.;3. Biotechnology Center, Grape King Inc., Taoyuan, Taiwan, R.O.C. |
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| Abstract: | Three new compounds, 2,4‐dimethoxy‐6‐methylbenzene‐1,3‐diol ( 1 ), salmoquinone ( 2 ), and 3‐(4‐hydroxyphenyl)‐4‐isobutyl‐1H‐pyrrole‐2,5‐dione ( 3 ), together with six known compounds, 2‐methoxy‐6‐methyl‐p‐benzoquinone ( 4 ), 2,3‐dimethoxy‐5‐methyl‐p‐benzoquinone ( 5 ), 2‐hydroxy‐5‐methoxy‐3‐methyl‐p‐benzoquinone ( 6 ), eburcoic acid ( 7 ), fomefficinic acid C ( 8 ), and a pyrroledione ( 9 ), were isolated from the mycelium of Antrodia salmonea. The structures of these compounds were elucidated by spectrometric analyses including IR, NMR, and MS. Among these compounds, 4 and 5 exhibited cytotoxicity against KB, HepG2, and H2058 cell lines. |
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| Keywords: | Antrodia salmonea Polyporaceae Mycelium Benzoquinone Cytotoxicity |
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