The Synthesis of N‐Glycosyl‐N′‐Pyrazolylmethylene Aminothioureas under a 4Å Molecular Sieve

A series of novel N‐glycosyl‐N′‐pyrazolylmethylene aminothioureas ( 4a‐4e, 5a‐5e ) were synthesized from N‐glycosyl‐N′‐aminothioureas ( 2a‐2d ) and 4‐formylpyrazole ( 3a‐3e ). Activated 4Å molecular sieves were adopted for dehydrated reagent to improve the reaction rate and yield. The structures of the new compounds were identified on the basis of IR, ¹H NMR and MS spectra. Simultaneously, the compounds were detected by fluorescence spectrophotometer and had preferable fluorescence activity, so they can be selected as a kind of novel fluorescence labeled derivative of sugar.