1. Department of Chemistry, K.N. Toosi University of Technology P.O.Box 15875‐4416;2. Tehran, Iran
Abstract:
5‐Aryl‐6H‐1,3,4‐thiadiazin‐2‐aminium and 5‐aryl‐N‐phenyl‐6H‐1,3,4‐thiadiazin‐2‐aminium salts have efficiently been synthesized from the reaction of thiosemicarbazide and α‐haloketones in acetonitrile at room temperature using i) silica supported sodium hydrogen sulfate and ii) silica sulfuric acid as reusable heterogeneous catalysts. The experimental procedure is simple and the products are obtained in high yields.