A New Diterpenoid and a New Diterpenoid Alkaloid from Aconitum coreanum |
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| Authors: | Chun‐Hua Yang Xia‐Chang Wang Qing‐Fa Tang Wen‐Ying Liu Jing‐Han Liu |
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| Affiliation: | 1. Center of Instrumental Analysis, China Pharmaceutical University, Nanjing 210009, P.?R. China;2. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, P.?R. China;3. Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, P.?R. China, (phone: +86‐25‐83271328;4. fax: +86‐25‐83271328);5. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, P.?R.?China |
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| Abstract: | A new diterpenoid, guan fu diterpenoid A ( 1 ), and a new diterpenoid alkaloid, guan fu base S ( 2 ), were isolated from the Chinese medicinal herb Aconitum coreanum (Lèvl. ) Rapaics , together with five known diterpenoid alkaloids guan fu base P, guan fu base R, guan fu base G, guan fu base F, and guan fu base Z. The structures of the two new compounds were elucidated as ent‐kaurane‐16,20‐diol ( 1 ) and (11β,13S)‐2,3,15,16‐tetradehydro‐16,17‐dihydrohetisan‐11,13,14‐triol 11,13‐diacetate ( 2 ) on the basis of HR‐MS and 2D‐NMR analyses. This is the first report of an ent‐kaurane diterpenoid in Aconitum coreanum. |
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| Keywords: | Aconitum coreanum Diterpenoids Alkaloids Guan fu diterpenoid A Guan fu base S |
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