New Acyclic 12‐Hydroxygeranylgeraniol‐Derived Diterpenoids from the Seeds of Carpesium triste |
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| Authors: | Xue Gao Zhan‐Xin Zhang Zhong‐Jian Jia |
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| Affiliation: | 1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.?R. China, (phone: +86?0931‐8911136;2. fax: +86?0931‐8912582) |
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| Abstract: | Five new acyclic 12‐hydroxygeranylgeraniol‐derived diterpenoids, i.e., 1 – 5 , were isolated from the seeds of Carpesium triste. The structures including the absolute configurations of the new compounds were elucidated by spectroscopic methods. All the compounds, except for 2 , were evaluated for their in vitro cytotoxic activity against cultured SMMC‐7721 (human hepatoma), HL‐60 (human promyelocytic leukemia), and L02 (human hepatocyte) cells. |
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| Keywords: | Carpesium triste Diterpenoids Cytotoxic activity |
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