A convenient synthesis of novel 1,3,4‐triaryl‐3,4‐dihydropyrimidin‐2(1H)‐ones by cyclization of aromatic isocyanates with β‐arylamino‐1‐phenylpropan‐1‐ones
1. ZJU‐ENS joint laboratory of medicinal chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang, P. R. China;2. Department of Chemical and Biochemical Engineering, College of Material Sciences and Chemical Engineering, Zhejiang University
Abstract:
A simple one‐step method for preparation of novel 1,3,4‐triaryl‐3,4‐dihydropyrimidin‐2(1H)‐ones has been developed by reaction of aromatic isocyanates with β‐arylamino‐1‐phenylpropan‐1‐ones in refluxing toluene in the presence of KHSO4 and HCl.
