2‐(1H‐Benzotriazole‐1‐yl)‐1,1,3,3‐Tetramethyluronium Tetrafluoro Borate (TBTU) as an Efficient Coupling Reagent for the Esterification of Carboxylic acids with Alcohols and Phenols at Room Temperature |
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| Authors: | Saeed BALALAIE Maryam MAHDIDOUST Rasoul ESHAGHI‐NAJAFABADI |
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| Institution: | 1. Peptide Chemistry Research Group, K. N. Toosi University of Technology, P.O. Box 15875‐4416, Tehran, Iran;2. Tofigh Daru Research and Engineering Company (TODACO), 61st Street, 18th Km Karaj Highway, P.O. Box 19395‐4978Tehran, Iran;3. Fax: 0098‐21‐22853650 |
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| Abstract: | Esterification of carboxylic acids with alcohols and phenols by using 2‐(1H‐benzotriazole‐1‐yl)‐1,1,3,3‐tetramethyluronium tetrafluoroborate (TBTU) in the presence of triethylamine as a base proceeded smoothly under mild conditions to afford the corresponding esters in good to high yields in acetonitrile at room temperature. |
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| Keywords: | uronium salt 2‐(1H‐benzotriazole‐1‐yl)‐1 1 3 3‐tetramethyluronium tetrafluoro borate (TBTU) esterification coupling reagent phenol and alcohol |
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