Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
Abstract:
Reaction of pyrimidinylacetic acid 2 with different electrophilic and nucleophilic reagents gave annulated pyrimidine derivatives 3‐11 , respectively. Compound 3 was transformed to pyrimidinylacetyl azide 12 , which upon heterocyclization with active methylene compounds, acidic and basic reagents furnished functionally substituted heteroaromatic compounds 13‐21 , respectively. The antimicrobial activity of some synthesized compounds was investigated. The structures of the synthesized derivatives were elucidated by elemental and spectral analyses.
