Three Novel Compounds from the Flowers of Bombax malabaricum |
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| Authors: | Jun Wu Xiao‐Hui Zhang Shu‐Wei Zhang Li‐Jiang Xuan |
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| Institution: | 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi‐Tech Park, Shanghai 201203, P.?R. China, (phone: +86‐21‐50272221;2. fax: +86‐21‐50272221) |
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| Abstract: | Two unusual 9′‐norneolignans, bombasin ( 1 ) and bombasin 4‐O‐β‐glucoside ( 2 ), and a novel D ‐gulono‐γ‐lactone derivative, bombalin ( 3 ), were isolated from the flowers of Bombax malabaricum, together with the three known compounds dihydrodehydrodiconiferyl alcohol 4‐O‐β‐D ‐glucopyranoside ( 4 ), trans‐3‐(p‐coumaroyl)quinic acid ( 5 ), and neochlorogenic acid ( 6 ). Their structures were elucidated by extensive spectroscopic methods as well as chemical transformation. Compounds 1 – 3 were evaluated against the HGC‐27 gastrointestinal and Hela cervical human cancer cell lines, but all were inactive in both lines (IC50>50 μM ). |
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| Keywords: | Bombax malabaricum Bombasin Bombalin Norneolignans D‐Gulono‐γ ‐lactones Enzymatic hydrolysis Antiproliferative activity Cytotoxic activity |
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