Novel biomimetic composite based on collagen and poly(γ‐benzyl L‐glutamate)‐co‐poly(glutamic acid) |
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| Authors: | Xiumiao Zhou Yingjun Wang Li Ren Lingyun Wang |
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| Institution: | 1. College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China;2. Polymer Research Institute, North University of China, Taiyuan 030051, People's Republic of China;3. Key Laboratory of Specially Functional Materials (South China University of Technology), Ministry of Education, Guangzhou 510640, People's Republic of China |
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| Abstract: | Novel biomimetic composite was prepared by the reaction of collagen and poly(γ‐benzyl L ‐glutamate)‐co‐poly(glutamic acid) (PBLG‐co‐PGA), which were crosslinked by non‐toxic crosslinking reagents 1‐ethyl‐(dimethylaminopropyl) carbodiimide (EDC) and N‐hydroxysuccinimide (NHS). The composite was characterized by FTIR and DSC. FTIR results confirmed that the collagen in the composite was successfully crosslinked with PBLG‐co‐PGA. DSC results showed that the composites possessed higher shrinkage temperature and higher thermal stability than the collagen. The water absorption test showed that the water absorbency of the composites increased with the increase in PBLG‐co‐PGA content in the composite. The studies of collagenase degradation and the tensile strength showed that the biostability and the tensile strength of the composites were significantly improved in comparison with that of the collagen. According to the investigations of cell adherent ratio and cell proliferation in vitro, the composite possessed good biocompatibility. Copyright © 2007 John Wiley & Sons, Ltd. |
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| Keywords: | biomimetic collagen poly(γ ‐benzyl L‐glutamate)‐co‐poly(glutamic acid) biocompatibility |
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