Biotransformation of Vermitaline by Cunninghamella echinulata |
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| Authors: | Yi‐Feng Lü Ke‐Yu Chen Hui‐Liang Li Yue‐Hu Pei Run‐Hui Liu Wei‐Dong Zhang |
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| Institution: | 1. School of Pharmacy, Second Military Medical University, Shanghai 200433, P.?R. China, (phone: +86‐21‐25070387;2. fax: +86‐21‐25070387);3. School of Traditional Chinese Materia Medica 49#, Department of Natural Medicinal Chemistry, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P.?R. China;4. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.?R. China, (phone: +86‐21‐25070386;5. fax: +86‐21‐25070386) |
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| Abstract: | Biotransformation of vermitaline ( 1 ) by Cunninghamella echinulata (ACCC 30369) was carried out. Four biotransformation products were obtained and three of them were characterized as new compounds. On the basis of their NMR and mass‐spectral data, their structures were characterized as 7α‐hydroxyrubijervine ( 2 ), 7α‐hydroxyrubijervine‐7‐O‐β‐D ‐galactofuranoside ( 3 ), 7α‐hydroxyvermitaline ( 4 ), and 7α‐hydroxyvermitaline‐7‐O‐β‐D ‐galactofuranoside ( 5 ). |
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| Keywords: | Cunninghamella echinulata Vermitaline Rubijervine 7α ‐hydroxy‐ |
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