Synthesis of 3‐Aryl‐2,5‐Dihydro‐1‐Benzoxepines from Phenol via Ring‐Closing Metathesis |
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| Authors: | Jui‐Chi Tsai Sie‐Rong Li Liang‐Yeu Chen Po‐Yuan Chen Jia‐Ying Joung Chung‐Jung Shu Yu‐Fuan Lo Chun‐Nan Lin Eng‐Chi Wang |
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| Institution: | 1. Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.;2. Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C. |
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| Abstract: | In this paper, the synthesis of 3‐aryl‐2,5‐dihydro‐1‐benzoxepines is described. While the reaction was started from phenol and based on the sequential reactions such as Claisen rearrangement, O‐alkylation, Wittig reaction, and ring‐closing metathesis (RCM), a series of new 3‐aryl‐1‐benzoxepines were prepared in good overall yields. |
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| Keywords: | 3‐Aryl‐2 5‐dihydro‐1‐benzoxepine Ring‐closing metathesis |
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