Two New C20‐Diterpenoid Alkaloids from the Tibetan Medicinal Plant Aconitum naviculare Stapf |
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| Authors: | Jin‐Xin Cao Liang‐Bo Li Jie Ren Si‐Ping Jiang Ren‐Rong Tian Xu‐Lin Chen Shu‐Lin Peng Jie Zhang Hua‐Jie Zhu |
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| Institution: | 1. Organic Synthesis State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.?R. China, (phone: +86?871?5216179;2. fax: +86?871?5216179);3. Graduate School of the Chinese Academy of Sciences, Beijing 100039, P.?R. China;4. Tibetan Plateau Institute of Biology, Lhasa, 850001, Tibet, P.?R. China;5. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, P.?R. China;6. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P.?R. China;7. Guiyang Medical University, Guiyang, 550004, P.?R. China |
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| Abstract: | Two new C20‐diterpenoid alkaloids named naviculine A ( 1 ) and naviculine B ( 2 ), were isolated from Aconitum naviculare Stapf . Their structures were established by spectral methods, especially 2D‐NMR spectra (1H,1H‐COSY, HMQC, HMBC, and NOESY) and DFT methods (at the B3LYP/6‐311++G(2d,p)//B3LYP/6‐31G(d) level), respectively. They were assayed for their anti‐HIV‐1 activity. |
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| Keywords: | Aconitum naviculare Diterpene alkaloids Alkaloids Naviculines A and B |
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