Functional Near‐Infrared Fluorescent Probes |
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| Authors: | Kazuki Kiyose Hirotatsu Kojima Dr. Tetsuo Nagano Prof. Dr. |
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| Affiliation: | 1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7‐3‐1, Hongo, Bunkyo‐ku, Tokyo 113‐0033, Japan, Fax: (+81)?3‐5841‐4855;2. CREST, JST, 4‐8‐1 Honcho, Kawaguchi, Saitama, 332‐0012, Japan |
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| Abstract: | Near‐infrared (NIR) fluorescent probes have attracted much attention, but despite the availability of various NIR fluorophores, only a few functional NIR probes, that is, probes whose absorption and/or fluorescence spectra change upon specific reaction with biomolecules, have been developed. However, functional probes operating in the NIR range that can be targeted to protons, metal ions, nitric oxide, β‐galactosidase, and cellular stress markers are expected to be effective for fluorescence imaging in vivo. This Focus Review concentrates on these functional NIR probes themselves, not their applications. |
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| Keywords: | biosensors electron transfer fluorescent probes functional probes ratiometric probes |
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