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A General Approach to Aza‐Heterocycles by Means of Domino Sequences Driven by Hydroformylation |
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| Authors: | Etienne Airiau Thomas Spangenberg Nicolas Girard Dr. Angèle Schoenfelder Jessica Salvadori Maurizio Taddei Prof. André Mann Dr. |
| Affiliation: | 1. Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7175/LC1, 74, route du Rhin, BP 60024, 67401 Illkirch (France), Fax: (+33)?390‐244‐310;2. Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro 2, 53100 Siena (Italy) |
| Abstract: | The development of hydroformylative domino reactions of easily accessible vinyl acetamides is described. Extremely regioselective hydroformylation of terminal double bounds provides a transient N‐acyliminium that can be trapped by various nucleophiles to give several aza‐heterocylic scaffolds in a diastereoselective manner. |
| Keywords: | cyclohydrocarbonylation diastereoselectivity domino reactions heterocycles hydroformylation |