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From Biological towards Artificial Molecular Motors
Authors:Moritz Mickler  Enrico Schleiff Prof Dr  Thorsten Hugel Prof Dr
Institution:1. Physics Department, IMETUM, CeNS and CIPSM, Technische Universit?t München, 85748 Garching (Germany), Fax: (+49)?89‐289‐12523;2. Molekulare Zellbiologie, JWGUF, CEF and IMBS, Universit?t Frankfurt, 60438 Frankfurt (Germany)
Abstract:Novel single‐molecule techniques allow the observation of single‐molecular motors in real time under physiological conditions. This enables one to gain previously inaccessible information about the mechanics of molecular motors, especially their mechano‐chemical coupling. As an example, we discuss the DNA import motor of the bacteriophage ?29 and protein import into chloroplasts. In contrast to these highly developed biological molecular motors, artificial molecular motors are still at an early stage of development. Nevertheless, they already give a wealth of information. Our review focuses on how the investigation of artificial and biological molecular motors can mutually enrich each other.
Keywords:atomic force microscopy  fluorescence  magnetic tweezers  molecular devices  single‐molecule studies
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