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Applications of Carbohydrate‐Gold Nanoparticles for Volumetric Flow Measurements Using an Opto‐Acoustic Technique |
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| Authors: | Chan‐Yi Yang Chen‐Wei Wei Yen‐Ping Lin Hsiao‐Chien Tseng Ya‐Na Wu Chia‐Chun Chen Dar‐Bin Shieh Pai‐Chi Li |
| Institution: | 1. Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan, R.O.C.;2. Department of Electrical Engineering, National Taiwan University, Taipei 106, Taiwan, R.O.C.;3. Institute of Molecular Medicine, National Cheng‐Kung University, Tainan 701, Taiwan, R.O.C.;4. Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, R.O.C.;5. Institute of Oral Medicine, National Cheng‐Kung University, Tainan 701, Taiwan, R.O.C.;6. Institute of Basic Medicine, National Cheng‐Kung University, Tainan 701, Taiwan, R.O.C. |
| Abstract: | Gold nanoparticles with carbohydrate ligands attached on their surface have been synthesized and characterized with various techniques. The new nanoparticle conjugates have shown great potentials as a contrast agent for opto‐acoustic imaging. Hemocompatibility measurements of human blood for the carbohydrate‐gold nanoparticles have shown that the conjugates are feasible for in vivo testing. Preliminary quantitative flow measurements using the conjugates were also studied in this work based on the indicator‐dilution theory. In vitro phantom experiments were designed and conducted, and results were discussed. |
| Keywords: | Carbohydrate‐AuNPs Opto‐acoustic imaging Time‐intensity curve |