1. Department of Medicinal Chemistry, Pharmacy Faculty, Mashhad University of Medical Sciences, Mashhad, P.O. Box 91775‐1365, Iran;2. Biotechnology and Pharmaceutical Research Center, Mashhad University of Medical sciences, Mashhad, Iran
Abstract:
The paper describes synthesis and antituberculosis activity of α‐[5‐(5‐amino‐1,3,4‐thiadiazol‐2‐yl)‐imidazol‐2‐ylthio]acetic acids ( 5a,b ). The compounds were tested against Mycobacterium tuberculosis strain H37Rv in comparison to rifampicin. Compounds exhibited low activity (MIC ≤ 6.25 μg/ml, % inhibition ≥ 24).
