Synthesis and In Vivo Anticonvulsant Screening of Coumarin Incorporated Schiff Bases of 1,3,4‐Oxadiazoles |
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Authors: | Nadeem Siddiqui Mashooq A. Bhat Suroor A. Khan Waquar Ahsan M. Shamsher Alam |
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Affiliation: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi‐110062, India |
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Abstract: | A series of coumarin incorporated Schiff bases of 1,3,4‐oxadiazoles ( 1‐18 ) was synthesized. The structures of the synthesized compounds were confirmed on the basis of spectral data and elemental analysis. The anticonvulsant and neurotoxicity was studied by maximal electroshock seizure (MES) and rotorod method, respectively. A majority of the compounds were active in MES test. All the compounds were less neurotoxic than the standard drug phenytoin. |
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Keywords: | Coumarin MES test 1,3,4‐Oxadiazoles Schiff bases |
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