Secondary Metabolites from the Leaves of Litsea lii var. nunkao‐tahangensis |
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| Authors: | Tzu‐Ann Wang Ming‐Jen Cheng Shiow‐Ju Lee Cheng‐Wei Yang Hsun‐Shuo Chang Ih‐Sheng Chen |
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| Affiliation: | 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, R.O.C. (phone: +886‐7‐3121101, ext 2191);2. T.‐A. W. and M.‐J. C. contributed equally to this work.;3. Current address: Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan 300, R.O.C.;4. Division of Biotechnology and Pharmaceutical Research, National Health Research Institute, Miaoli, Taiwan 300, R.O.C. |
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| Abstract: | Investigation of the leaves extract of Litsea lii var. nunkao‐tahangensis led to the isolation of five new butanolides, litsealiicolide A ( 1 ), isolitsealiicolide A ( 2 ), litsealiicolide B ( 3 ), isolitsealiicolide B ( 4 ), and isolitsealiicolide C ( 5 ), along with 17 known compounds. Their structures were determined through in‐depth spectroscopic and mass‐spectrometric analyses. Among the isolates, compounds 1 and 2 were cytotoxic against MCF‐7, NCI‐H460, and SF‐268 cell lines in vitro. Compound 5 and isolinderanolide B ( 6 ) showed marginal cytotoxic activity against these three cell lines in vitro. |
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| Keywords: | Litsea lii var. nunkao‐tahangensis Butanolides Litsealiicolides A and B Isolitsealiicolides A – C Cytotoxic activity |
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