New Antifungal Terpenoid Glycosides from Alibertia edulis (Rubiaceae) |
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| Authors: | Viviane Cândida da Silva Maria José Soares Mendes Giannini Virginia Carbone Sonia Piacente Cosimo Pizza Vanderlan da Silva Bolzani Márcia Nasser Lopes |
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| Institution: | 1. Chemistry Institute, S?o Paulo State University, UNESP, C.P. 355, CEP 14801‐970, Araraquara, S?o Paulo, Brazil (phone: +55‐16‐33016662;2. fax: +55‐16‐33016692);3. Faculty of Pharmaceutical Sciences, S?o Paulo State University, UNESP, CEP 14801‐902, Araraquara, S?o Paulo, Brazil;4. Proteomic and Biomolecular Mass Spectrometry Center, Institute of Food Science, CNR, Via Roma, 52 a/c, I‐83100, Avellino;5. Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, via Ponte Don Melillo, I‐84084 Fisciano (SA) |
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| Abstract: | Phytochemical investigation from the stems of Alibertia edulis led to the isolation and identification of a new iridoid 6β‐hydroxy‐7‐epigardoside methyl ester ( 1 ) and a new saponin 3β‐O‐α‐L ‐rhamnopyranosyl‐(1→2)‐O‐β‐D ‐glucopyranosyl‐(1→2)‐O‐β‐D ‐glucopyranosyl]‐28‐O‐β‐D ‐glucopyranoside pomolate ( 2 ), along with three known compounds, shanzhiside methyl ester ( 3 ), ixoside ( 4 ), and 3,4,5‐trimethoxyphenyl 1‐O‐β‐D ‐apiofuranosyl‐(1→6)‐O‐β‐D ‐glucopyranoside ( 5 ). The structures of 1 and 2 were established on the basis of their spectroscopic data. Iridoid 1 and saponin 2 exhibited moderate inhibitory activities against Candida albicans and C. krusei in a dilution assay. |
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| Keywords: | Alibertia edulis Antifungal activity Terpenoid glycosides Glycosides Iridoids |
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