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Field‐Effect Nanoparticle‐Based Glucose Sensor on a Chip: Amplification Effect of Coimmobilized Redox Species |
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| Authors: | Jenny Gun Michael?J Schöning Maryam?H Abouzar Arshak Poghossian Evgeny Katz |
| Institution: | 1. Institute of Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel;2. Aachen University of Applied Sciences, Jülich Campus, Institute of Nano‐ and Biotechnologies (INB), Ginsterweg 1, 52428 Jülich, Germany;3. Research Centre Jülich, Institute of Bio‐ and Nanosystems (IBN), 52425?Jülich, Germany;4. Department of Chemistry and Biomolecular Science and NanoBio Laboratory (NABLAB), Clarkson University, Potsdam NY 13699‐5810, USA |
| Abstract: | A capacitive EIS (electrolyte‐insulator‐semiconductor) structure was modified with gold nanoparticles together with glucose oxidase and used as field‐effect‐based glucose biosensor using the constant capacitance mode. Co‐immobilization of ferrocene redox species resulted in a two‐fold increase of the biosensor sensitivity. The effect was explained by the hydrogen peroxide‐mediated oxidation of ferrocene resulting in a pool of charged species at the interface increasing the sensor response towards glucose. The studied approach was suggested as a general means to amplify signals from Si chip‐based field‐effect enzyme biosensors. |
| Keywords: | Glucose sensor Capacitive EIS (electrolyte‐insulator‐semiconductor) structure Field‐effect sensor Glucose oxidase Functionalized nanoparticle |