Synthesis,structure and investigations of tuberculosis inhibition activities of new 4‐methyl‐1‐substituted‐1H‐1,2,4‐triazole‐5(4H)‐thione期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis,structure and investigations of tuberculosis inhibition activities of new 4‐methyl‐1‐substituted‐1H‐1,2,4‐triazole‐5(4H)‐thione

Authors:	Monika Wujec Agata Siwek Marta Swatko‐Ossor Liliana Mazur Zofia Rzaczynska

Affiliation:	1. Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20‐081 Lublin, Poland;2. +48815357373;3. Department of Biochemistry, Medical University, Chodzki 1, Lublin, Poland;4. Department of General and Coordination Chemistry, Faculty of Chemistry, Maria Curie‐Sklodowska University, 20‐031 Lublin, Poland

Abstract:	By the reaction aminomethylation, chloromethylation and acylation of 4‐methyl‐4H‐1,2,4‐triazole‐3‐thiol, 4‐methyl‐1‐substituted‐1H‐1,2,4‐triazole‐5(4H)‐thione 1‐8 were obtained. Molecular structure of the obtained compounds was confirmed by an elemental analysis, IR, ¹H NMR and ¹³C NMR spectra and additionally by X‐ray analysis for 2. Six new compounds 1,2,4‐7 were tested for antibacterial activity against Mycobacterium smegmatis, Mycobacterium phlei and avirulent strain Mycobacterium H₃₇Ra.

Keywords: