Oligonucleotide Analogues with Integrated Bases and Backbones. Part 19. |
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Authors: | Nicolas Bogliotti Anne Ritter Séverine Hebbe Andrea Vasella |
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Institution: | Laboratorium für Organische Chemie, ETH Zürich, Wolfgang‐Pauli Strasse 10, CH‐8093 Zürich |
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Abstract: | The A*s]U(*) dinucleosides 1 and 2 form thermoreversible gels in organic solvents. The basis of the gelation is the formation of linear aggregates by base pairing following desolvation of the nucleobases. This is evidenced by the absence of gel formation by the C(6)‐deaminated analogue 3 of 1 , the correlation of gelation with the anti‐conformation, as preferred for 1 , and the temperature‐, concentration‐, and time‐dependent CD spectra. The gels were also characterized by the minimum gelation concentration, the gel–sol transition (melting) temperature, and rheological properties. |
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Keywords: | Gels Rheology Nucleosides Oligonucleotides Purines Adenosines Ribofuranosyl purines Deamination of adenosines Gel– sol transition Hydrogen bonding |
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