首页 | 本学科首页   官方微博 | 高级检索  
     


Preparation of 1H‐1,2,3‐Triazoles by Cuprous Ion Mediated Cycloaddition of Terminal Alkyne and Sodium Azide
Authors:Li‐Hui Lu  Jia‐Hao Wu  Chia‐Hsi Yang
Affiliation:Department of Chemistry, Chung‐Yuan Christian University, Chung‐Li 32023, Taiwan, R.O.C.
Abstract:1H‐1,2,3‐triazoles can be prepared in good yield by the reaction of terminal alkyne and sodium azide in the presence of cuprous chloride at a temperature higher than 70°C. The alkyne is unactivated and the reaction has to be carried out under inert gas. At room temperature, the reaction first gives a Cu(I)‐azide complex which is converted to a Cu‐alkyne complex when the temperature is raised to higher than 70°C. The reaction of Cu(I)‐alkyne complex and azide ion dissociated from or coordinated to Cu(I) then gives 1H‐1,2,3‐triazoles.
Keywords:1H‐1,2,3‐Triazole  Alkyne  Cuprous chloride  Sodium azide
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号