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Synthesis of Morphlinotetrahydrothieno[2,3‐c]Isoquinolines
Authors:Adel M. Kamal El‐Dean  Shaban M. Radwan  Remon M. Zaki
Affiliation:Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
Abstract:1‐Morpholin‐4‐yl‐5,6,7,8‐tetrahydroisoquinoline‐4‐carbonitrile ( 2 ) was synthesized from 3‐amino‐1‐thioxo‐5,6,7,8‐tetrahydro‐1H‐isothiochromene‐4‐carbonitrile ( 1 ) and used as starting material to synthesize many thienotetrahydroisoquinolines ( 4 ), which in turn were used in the synthesis of many pyrimidothienotetrahydroisoquinolines.
Keywords:Synthesis  Reactions  Tetrahydroisoquinolines  Thienotetrahydroisoquinolines  Pyrimidothienotetrahydroisoquinolines
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