Chemical Constituents from the Bark of Garcinia xanthochymus and Their 1,1‐Diphenyl‐2‐picrylhydrazyl (DPPH) Radical‐Scavenging Activities |
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Authors: | Fang‐Fang Zhong Yu Chen Guang‐Zhong Yang |
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Institution: | 1. Laboratory for Natural Product Chemistry, College of Life Sciences, South Central University for Nationalities, Wuhan 430074, P.?R. China, (phone: +86‐27‐67842689;2. fax: +86‐27‐67842689);3. College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074, P.?R. China |
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Abstract: | A new bis‐xanthone (xanthone=9H‐xanthen‐9‐one), named bigarcinenone A ( 1 ) which is the first example of a bis‐xanthone with the xanthone–xanthone linkage between an aromatic C‐atom and a C5 side chain from a guttiferae plant, a new phloroglucinol (=benzene‐1,3,5‐triol) derivative, named garcinenone F ( 2 ), together with seven known xanthones were isolated from the bark of Garcinia xanthochymus. Their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. Bigarcinenone A ( 1 ) exhibited potent antioxidant activity in the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical‐scavenging test with a IC50 value of 9.2 μM , compared to the positive control, the well‐known antioxidant butylated hydroxytoluene (BHT) with a IC50 of 20 μM (Table 3). |
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Keywords: | Garcinia xanthochymus Bis‐xanthone Xanthone Phloroglucinol Bigarcinenone A Garcinenone F |
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