Nortriterpenoids from Schisandra wilsoniana |
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| Authors: | Guang‐Yu Yang Wei‐Lie Xiao Ying Chang Rui‐Rui Wang Jian‐Xin Pu Xue‐Mei Gao Chun Lei Yang Lu Yong‐Tang Zheng Han‐Dong Sun |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P.?R. China, (phone: +86‐871‐5223251;2. fax: +86‐871‐5216343);3. Graduate School of Chinese Academy of Sciences, Beijing 100039, P.?R. China;4. Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, P.?R. China;5. Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, P.?R. China |
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| Abstract: | Three new highly oxygenated nortriterpenoids, wilsonianadilactones A–C ( 1 – 3 ), together with twelve known ones, i.e., 4 – 15 , were isolated from the leaves and stems of Schisandra wilsoniana. Their structures were established by means of extensive analysis of spectroscopic data, and compound 1 was further confirmed by X‐ray crystallographic diffraction. Compounds 1 – 3 showed weak anti‐HIV‐1 activity with EC50 values of 23.5, 55.5, and 66.4 μg/ml, respectively. |
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| Keywords: | Schisandra wilsoniana Nortriterpenoids Wilsonianadilactones A – C X‐Ray crystallography |
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