Synthesis and characterization of serial random and block-copolymers based on lactide and glycolide |
| |
| Authors: | Zongrui Zhang Xinyu Wang Rong Zhu Yiyu Wang Binbin Li Yanxu Ma Yixia Yin |
| |
| Institution: | 1.State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan,China;2.Biomedical Materials and Engineering Research Center of Hubei Province,Wuhan University of Technology,Wuhan,China |
| |
| Abstract: | The objective of this study is to investigate the properties of poly(lactide-co-glycolide) with different composition ratios and PLGA-PEG-PLGA copolymers synthesized by ring-opening polymerization method. Their compositions, crystallization properties, thermal and degradation behaviors, hydrophilicity and biocompatibility were studied. Our results demonstrate that poly(lactide-co-glycolide) with a 90% lactide and PLGA-PEG-PLGA show some crystallization properties. While as the decrease of lactide content in polymers, poly(lactide-co-glycolide) become amorphous, whereas, their hydrophilicity have been improved on the contrary. Compared to poly(lactide-co-glycolide), the PLGA-PEG-PLGA copolymer has a better hydrophilicity for the existence of polyethylene glycol block. Furthermore, both these polymers display easy controlled degradation properties and good cell compatibility. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
