The cucurbit[n]uril family |
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Authors: | Lagona Jason Mukhopadhyay Pritam Chakrabarti Sriparna Isaacs Lyle |
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Institution: | Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. |
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Abstract: | In 1981, the macrocyclic methylene-bridged glycoluril hexamer (CB6]) was dubbed "cucurbituril" by Mock and co-workers because of its resemblance to the most prominent member of the cucurbitaceae family of plants--the pumpkin. In the intervening years, the fundamental binding properties of CB6]-high affinity, highly selective, and constrictive binding interactions--have been delineated by the pioneering work of the research groups of Mock, Kim, and Buschmann, and has led to their applications in waste-water remediation, as artificial enzymes, and as molecular switches. More recently, the cucurbitn]uril family has grown to include homologues (CB5]-CB10]), derivatives, congeners, and analogues whose sizes span and exceed the range available with the alpha-, beta-, and gamma-cyclodextrins. Their shapes, solubility, and chemical functionality may now be tailored by synthetic chemistry to play a central role in molecular recognition, self-assembly, and nanotechnology. This Review focuses on the synthesis, recognition properties, and applications of these unique macrocycles. |
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Keywords: | cucurbituril molecular machines molecular recognition supramolecular chemistry |
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