Aminolysis of 5-Phenyl-2-tetrazolylacetic Acid Ethyl Ester |
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| Authors: | S M Putis V Yu Zubarev V S Poplavskii V A Ostrovskii |
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| Institution: | (1) St. Petersburg State Technological Institute (Technical University), Saint Petersburg, 198013, Russia |
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| Abstract: | It was shown using 5-phenyl-2-tetrazolylacetic acid ethyl ester as an example that aminolysis is a competitive method of synthesizing primary amides. The efficiency of aminolysis by primary amines is linked to the basicity of the initial amine. Highly basic amines display more high reactivity independent of the spatial structure of the substituent. Reaction of the investigated ester with secondary amines occurs ambiguously. |
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| Keywords: | 5-phenyl-2-tetrazolylacetamides 5-phenyl-2-tetrazolylacetic acid ethyl ester aminolysis |
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