CHLORPROMAZINE PHOTOSENSITIZATION—I. EFFECT OF NEAR-UV IRRADIATION ON BACTERIOPHAGES SENSITIZED WITH CHLORPROMAZINE |
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| Authors: | Itsuro Matsuo Muneo Ohkido Hitoshi Fijita Kenshi Suzuki |
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| Affiliation: | *Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa. 259–11, Japan;†Department of Molecular Biology, Tokai University School of Medicine, Isehara, Kanagawa. 259–11, Japan |
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| Abstract: | Abstract— Both DNA bacteriophage and RNA bacteriophage were inactivated when they were irradiated with near-UV light (black light) in the presence of chlorpromazine. The far-UV sensitive mutants of T4D, i.e. T4D v , T4D px and T4D y , were no more sensitive to near-UV light plus chlorpromazine than the wild type. Electron microscopic observations showed that adsorption of T4D was greatly influenced by the treatment. The present results may indicate that the inactivation of T4D is due to the loss of adsorption caused by impairment in the tail or the tail fiber protein rather than the inactivation of DNA. |
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