Synthesis of 3,9-dialkylguanines and their conversion into 3-alkylwyes,models for the fluorescent nucleosides from phenylalanine transfer ribonucleic acids |
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| Authors: | Taisuke Itaya Kazuo Ogawa |
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| Institution: | Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920, Japan |
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| Abstract: | Synthesis of 3,9-dialkylguanines 5 has been accomplished by N-cyanation of 1-alkyl-5-(alkylamino)imidazole-4- carboxamides 3 followed by base-catalysed cyclisation. Cyclocondensation of 9-alkyl-3-methylguanines 5a, d, f with MeCOCH2Br gave 3-alkylwyes 6, model compounds of the most probable structure for wyosine from Torulopsis utilis tRNAPhe. |
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