| 星形PLA-PEG嵌段共聚物胶束的制备与表征 |
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| 引用本文： | 陈一纾,岩晓丽,梁洁,樊渝江.星形PLA-PEG嵌段共聚物胶束的制备与表征[J].化学研究与应用,2010,22(10). |
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| 作者姓名： | 陈一纾 岩晓丽 梁洁 樊渝江 |
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| 作者单位： | 四川大学国家生物医学材料工程技术研究中心,四川成都,610064 |
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| 摘 要： | 以胆酸为引发剂,用辛酸亚锡催化丙交酯开环聚合合成星型CA-PLA。利用DCC为脱水剂,将不同分子量的端羧基化PEG与星型CA-PLA偶联,合成一系列以胆酸为核的星形两亲性嵌段共聚物,用透析法制备共聚物胶束,并用TEM和DLS研究胶束的性质。合成了分子量为6000和12000的两种CA-PLA,其分子量可以通过胆酸羟基与丙交酯的比例进行控制。将分子量2000和5000的PEG分别与两种CA-PLA偶联,合成了四种星型CA-PLA-PEG嵌段共聚物。共聚物胶束形貌为均匀的球形,粒径为20-40nm,且随共聚物中PLA链段分子量的增加而增大,随PEG链段分子量的增加而减小。临界胶束浓度(CMC)低于同等链段长度的线型PLA-PEG嵌段共聚物胶束。
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| 关 键 词： | 两亲性嵌段共聚物 星形聚合物 高分子胶束 临界胶束浓度 |
Preparation and characterization of star-shaped PLA-PEG block copolymer micelles |
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| CHEN Yi-shu,YAN Xiao-li,LIANG Jie,FAN Yu-jiang.Preparation and characterization of star-shaped PLA-PEG block copolymer micelles[J].Chemical Research and Application,2010,22(10). |
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| Authors: | CHEN Yi-shu YAN Xiao-li LIANG Jie FAN Yu-jiang |
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| Institution: | CHEN Yi-shu,YAN Xiao-li,LIANG Jie,FAN Yu-jiang(National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610064,China) |
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| Abstract: | Amphiphilic copolymer micelles have been widely investigated for a long period as carriers for drug delivery.In this research,micelles based on star-shaped PLA-PEG block copolymers with cholic acid core was prepared and characterized,anticipating that it can obtain high molecular weight while reducing its molecular size,thus improving its stability during aggregating in aqueous solution.Star-shaped PLA-PEG block copolymers with cholic acid core were synthesized through ring-opening polymerization of lactide... |
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| Keywords: | amphiphilic block copolymer star shaped polymer micelle CMC |
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