Co-assembly of human islet amyloid polypeptide (hIAPP)/insulin |
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| Authors: | Liu Peng Zhang Shuai Chen Mei-sha Liu Qian Wang Chenxuan Wang Chen Li Yan-Mei Besenbacher Flemming Dong Mingdong |
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| Institution: | Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China. |
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| Abstract: | The pathogenesis of type II diabetes can be linked to cosecreted hIAPP/insulin interacting with cell membranes. Here we investigate the nanostructures by co-assembling hIAPP and insulin on surfaces. By tuning the hIAPP/insulin ratio, atomic force microscopy reveals the resulting nanostructure morphology changes from fibrils to oligomers, to annular. Implications for in vivo studies are discussed. |
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