| 非经典铂类抗肿瘤药物研究 |
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| 引用本文： | 王联红,刘芸,尤启冬,苟少华. 非经典铂类抗肿瘤药物研究[J]. 化学进展, 2004, 16(3): 456-462 |
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| 作者姓名： | 王联红 刘芸 尤启冬 苟少华 |
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| 作者单位： | 中国药科大学药学院,南京,210009;南京大学配位化学国家重点实验室,南京,210093;南京大学配位化学国家重点实验室,南京,210093;中国药科大学药学院,南京,210009 |
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| 摘 要： | 本文综述了非经典铂类抗肿瘤药物的发展概况,介绍了具有口服活性的铂(Ⅳ)配合物,具有空间位阻的铂(Ⅱ)配合物,反式铂(Ⅱ、Ⅳ)配合物,多核铂(Ⅱ)配合物和含有铂-硫键的铂(Ⅱ)配合物,并总结了这几类新型铂配合物的抗肿瘤机理,克服顺铂的耐药性机理及其临床进展。
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| 关 键 词： | 铂类抗肿瘤药物 非经典构效关系 口服活性 交叉耐药 抗肿瘤机理 |
| 文章编号： | 1005-281X(2004)03-0456-07 |
| 收稿时间： | 2003-01-01 |
| 修稿时间： | 2003-01-01 |
Progress in Non-classical Antitumor Platinum Drugs |
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| Wang Lianhong,Liu Yun,You Qidong,Gou Shaohua. Progress in Non-classical Antitumor Platinum Drugs[J]. Progress in Chemistry, 2004, 16(3): 456-462 |
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| Authors: | Wang Lianhong Liu Yun You Qidong Gou Shaohua |
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| Affiliation: | (1. School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; 2. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China) |
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| Abstract: | The progress in non-classical antitumor platinum drugs are reviewed. These potential drugs include orally active platinum(IV)complexes, sterically hindered platinum(II) complexes, trans-platinum(II -> IV) complexes, multinu-clear platinum(II) complexes and sulphur-containing platinum (II) complexes. Their antitumor mechanisms, advantages overcoming cisplatin resistance and clinical trials are summarized. |
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| Keywords: | antitumor platinum drugs non-classical structure-activity relationship orally activity cross-resistance antitumor mechanism |
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