Tandem addition of trialkyl phosphites to alpha,beta-unsaturated imines: a comparison with silylated phosphites |
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Authors: | Van Meenen Ellen Moonen Kristof Verwée Annelies Stevens Christian V |
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Affiliation: | Research Group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. |
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Abstract: | Trialkyl phosphites were evaluated for addition reactions to alpha,beta-unsaturated imines. An acidic medium is required to allow consecutive 1,4- and 1,2-addition to occur. In this manner, 3-phosphonyl-1-aminophosphonates, phosphonic acid analogues of glutamate, are obtained in good yields (32-90%). The reaction is mainly influenced by the steric bulk of the nitrogen substituent: less steric N-substituents lead to better yields of the tandem adducts. |
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