Preparation of Silyl Ethers Using Hexamethyldisilazane in the Presence of N‐Bromosuccinimide under Mild and Solvent‐Free Conditions |
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| Authors: | Hamid Reza SHATERIAN Razieh DOOSTMOHAMMADI Majid GHASHANG |
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| Institution: | 1. Tel.: 0098‐541‐2446565;2. Fax: 0098‐541‐2431067;3. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, PO Box 98135‐674, Zahedan, Iran |
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| Abstract: | A mild, simple, novel and highly efficient method for the rapid protection of various primary, secondary, tertiary aliphatic and aromatic alcohols using hexamethyldisilazane (HMDS) in the presence of N‐bromosuccinimide (NBS) as an active, inexpensive, non‐toxic and readily available catalyst under solvent‐free conditions is described. Trimethylsilyl ethers were prepared in high to excellent yields with short reaction time under mild and almost neutral reaction conditions. |
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| Keywords: | silylation alcohol oxime hexamethyldisilazane N‐bromosuccinimide catalyst |
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