Reaction of alpha,alpha-dibromo oxime ethers with Grignard reagents: alkylative annulation providing a pyrimidine core |
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Authors: | Kakiya Hirotada Yagi Kazunari Shinokubo Hiroshi Oshima Koichiro |
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Affiliation: | Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan. |
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Abstract: | A convergent synthesis of a pyrimidine core has been achieved. Treatment of alpha,alpha-dibromo oxime ethers, which are easily derived from the corresponding esters, with a variety of Grignard reagents provides trisubstituted pyrimidines in good yields. This new method offers an easy access to functionalized pyrimidines. |
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