Quantifying induced electric field strengths during gene transfer to the intact rat vasculature |
| |
| Authors: | Chris Capaccio Nikolay S. Stoykov Raji Sundararajan David A. Dean |
| |
| Affiliation: | 1. Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA;2. Division of Pulmonary & Critical Care, Northwestern University Medical School, Chicago, IL 60611, USA;3. Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA;4. Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60671, USA;5. Electronics & Computer Engineering Technology Department, Arizona State University East, Mesa, AZ 85212, USA |
| |
| Abstract: | The application of appropriate electric fields to cells and tissues, termed electroporation, can result in efficient and safe gene transfer. We have shown previously that this approach results in high level gene transfer to and expression in the vasculature of living animals. This paper presents the results of an electric field distribution study of a rat mesenteric vasculature model using the Finite-Element Time-Domain (FETD) technique. A novelty of this work is the use of Debye dispersive dielectric parameters, as the electrical response of biological tissues is inherently frequency-dependent. The results compare fairly well with experimental findings. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
