4-R-6-羟甲基-2-[N-(苯并氮杂-15-冠-5)甲基]苯酚的合成及晶体结构

以酚羟基为中心功能基的多齿配体可以络台多种金属离子,形成单核或双核金属络合物。合成含酚羟基多齿配体时,一般总是先把酚羟基用硫酸二甲酯醚化加以保护,在完成其它反应之后,再用去甲基化试剂还原出酚羟基。从原料盼到最终产:品的获得,至少需要进行五步反应。我们采用不保护酚羟基的合成路线,

Synthesis and Structure of 4-R-6-Hydroxyl Methyl-2-N-(benzoaza-15-crown-5) Methyl Phenols

In the present communition a novel synthetic route to the title compounds is described where in 4-R-2. 6-dihydroxymethyl phenols (R=substituents) are Converted to the dichloromethyl counterparts by the action of gaseous dry hydrogen cbloride without protection of the phenolic hydroxyl grop. The crude intermediates thus obtained are then reacted directly with benzoasa-15-crown-5. The polydentates thus resulting are shown to consist of both acyclic and cyclic structures of which one is elucidated, by four circle X- ray diffraction on its single crystal.